3H-Apomorphine interactions with dopamine receptors in calf brain |
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| Authors: | L Thal I Creese S H Snyder |
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| Institution: | 1. Departments of Pharmacology and Experimental Therapeutics and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, U.S.A.;1. Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, U.S.A. |
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| Abstract: | 3H-apomorphine binds to membranes from areas of the corpus striatum and limbic system of calf brain saturable and with a drug specificity indicating that it labels dopamine receptors. In terms of drug specificity, log-logit displacement curve slopes and number of binding sites, 3H-apomorphine interacts with receptors in a manner more like 3H-dopamine than 3H-haloperidol. These properties of 3H-apomorphine binding are those of an apparently "pure" agonist in contrast to the partial agonist effects of apomorphine upon the dopamine-sensitive adenylate cyclase. |
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| Keywords: | Dopamine receptor Neuroleptic |
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