| 电流密度和pH对奥旦西酮体外离子导入的影响 |
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| 引用本文： | 丁平田,魏刚,卞生杰,郑俊民. 电流密度和pH对奥旦西酮体外离子导入的影响[J]. 沈阳药科大学学报, 2000, 17(3): 157-159 |
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| 作者姓名： | 丁平田 魏刚 卞生杰 郑俊民 |
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| 作者单位： | 沈阳药科大学药学系,沈阳,110015 |
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| 摘 要： | 以小鼠全皮为渗透屏障膜 ,考察了电流密度和 pH对奥旦西酮体外离子导入的影响 .在实验电流范围内 ,药物的稳态流量与电流密度呈正比 ,但不是严格的线性关系 ;稳态流量与pH的关系图呈“S”型 ,因为pH的变化导致了药物解离度的改变
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| 关 键 词： | 奥旦西酮 离子导入 电流密度 pH |
| 修稿时间： | :1999-08-3 |
The Effects of Current Density and pH on the Iontophoresis of Ondansetron in vitro |
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| Ding Pingtian,Wei Gang,Bian Shengjie,Zheng Junmin. The Effects of Current Density and pH on the Iontophoresis of Ondansetron in vitro[J]. Journal of Shenyang Pharmaceutical University, 2000, 17(3): 157-159 |
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| Authors: | Ding Pingtian Wei Gang Bian Shengjie Zheng Junmin |
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| Abstract: | The effects of current density and pH on the iontophoresis of ondansetron(ON)across the full thickness of a mouse′ skin were studied.The steady state flux of ON rose proportionally as the current density applied across the skin was increased in the current density range of 0 05～0 3 mA/cm 2.However,there was no strict linear relationship.The profile of the relationship between the state flux and the pH was an“S” type,as a result of that the ionization degree could be controlled by the change of pH. |
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| Keywords: | ondansetron iontophoresis current density pH |
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