<Emphasis Type="Italic">Saikokaryukotsuboreito</Emphasis>, a herbal medicine,prevents chronic stress-induced anxiety in rats: comparison with diazepam |
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Authors: | Kazushige Mizoguchi Ryuji Ikeda Hirotaka Shoji Yayoi Tanaka Xue-Long Jin Yoshio Kase Shuichi Takeda Wakako Maruyama Takeshi Tabira |
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Institution: | (1) Department of Geriatric Medicine, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan;(2) Department of Physiology, Tianjin Medical University, 22 Qixiangtai, Tianjin, 300070, China;(3) Central Research Laboratories, Tsumura &; Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan;(4) National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan |
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Abstract: | Anxiety is frequently observed in several neuropsychiatric disorders, and stress is thought to precipitate or exacerbate anxiety.
In this study, the anxiolytic action of a herbal medicine, saikokaryukotsuboreito, (SRBT) was examined in normal healthy rats using the elevated plus-maze test. Moreover, the improving effect of SRBT on chronic
stress-induced anxiety was also examined. Single administration of SRBT did not have anxiolytic action in normal rats. Repeated
administration of SRBT significantly improved chronic stress-induced anxiety. On the other hand, single administration of
a typical anxiolytic, diazepam, had anxiolytic action in normal rats but repeated administration did not improve chronic stress-induced
anxiety. These results suggest that SRBT does not have anxiolytic activity equivalent to that of diazepam but has potency
for improving stress-related anxiety. This finding provides information important for the treatment of anxiety. |
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Keywords: | Saikokaryukotsuboreito Stress Anxiety Elevated plus-maze test Rat |
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