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| 活动期溃疡性结肠炎患者尿单核细胞趋化因子-1临床分析 | |
| 引用本文： | 张爽,梅俏,许建明,胡乃中,张旭,张丽萍,刘晓昌. 活动期溃疡性结肠炎患者尿单核细胞趋化因子-1临床分析[J]. 胃肠病学, 2011, 16(5): 298-300. DOI: 10.3969/j.issn.1008-7125.2011.05.010 |
| 作者姓名： | 张爽 梅俏 许建明 胡乃中 张旭 张丽萍 刘晓昌 |
| 作者单位： | 1. 安徽医科大学第一附属医院消化内科安徽省消化病重点实验室,230022;安徽省蚌埠市第三人民医院消化内科 2. 安徽医科大学第一附属医院消化内科安徽省消化病重点实验室,230022 3. 安徽省蚌埠市第三人民医院消化内科 |
| 摘 要： | 背景：单核细胞趋化因子（MCP）-1在溃疡性结肠炎（UC）发病中起重要作用。目的：探讨活动期UC患者尿MCP-1的变化及其临床意义。方法：纳入50例活动期UC患者和25例正常对照者，以ELISA法检测所有入选者的尿MCP-1水平，并与UC患者的主要临床病理特征行相关性分析。结果：活动期UC患者尿MCP-1水平显著高于正常对照组[（33．24±16．84）pg／ml对（16．47±7．73）pg／ml，P〈0．05]。UC患者尿MCP-1水平与疾病严重程度、病变范围、营养风险相关（P〈0．05），但与疾病临床类型、内镜分级不相关（P〉0．05）。结论：活动期UC患者尿MCP-1水平增高．且与UC疾病严重程度、病变范围和营养风险相关。 |
| 关 键 词： | 单核细胞趋化因子-1 趋化因子，CC 结肠炎，溃疡性 酶联免疫吸附测定 |
Clinical Analysis of Urinary Monocyte Chemoattractant Protein-1 in Patients with Active Ulcerative Colitis |
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| ZHANG Shuang,MEI Qiao,XU Jianming,HU Naizhong,ZHANG Xu,ZHANG Liping,LIU Xiaochang. Clinical Analysis of Urinary Monocyte Chemoattractant Protein-1 in Patients with Active Ulcerative Colitis[J]. Chinese Journal of Gastroenterology, 2011, 16(5): 298-300. DOI: 10.3969/j.issn.1008-7125.2011.05.010 | |
| Authors: | ZHANG Shuang MEI Qiao XU Jianming HU Naizhong ZHANG Xu ZHANG Liping LIU Xiaochang |
| Affiliation: | ZHANG Shuang,MEI Qiao,XU Jianming,HU Naizhong,ZHANG Xu,ZHANG Liping,LIU Xiaochang.Department of Gastroenterology,The First Affiliated Hospital of Anhui Medical University The Key Laboratory for Digestive Diseases of Anhui Province,Hefei(230022) |
| Abstract: | Background:Monocyte chemoattractant protein-1(MCP-1)plays an important role in the pathogenesis of ulcerative colitis(UC).Aims:To investigate the change of urinary MCP-1 in patients with active UC and its clinical significance. Methods:Fifty patients with active UC and 25 healthy controls were enrolled in this study,and urinary level of MCP-1 of the subjects was measured by ELISA.The correlations between urinary level of MCP-1 and the main clinicopathological features of patients with UC were analyzed.Resul... |
| Keywords: | Monocyte Chemoattractant Protein-1 Chemokines CC Colitis Ulcerative Enzyme-Linked Immunosorbent Assay |
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