Release of endogenous 5-hydroxytryptamine from the intermediate lobe of the rat pituitary gland is inhibited by endogenous dopamine |
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| Authors: | K Racké M Holzbauer D F Sharman |
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| Affiliation: | 1. A.F.R.C. Institute of Animal Physiology, Babraham, Cambridge CB2 4AT U.K.;2. Department of Pharmacology, University of Mainz, D-6500 Mainz F.R.G.;1. School of Flexible and Printable Electronics, LANL-CBNU Engineering Institute-Korea, Chonbuk National University, 664-14, Deokjin-dong, Deokjin-gu, Jeonju-si, Jeollabuk-do, 561-756, Republic of Korea;2. Department of Physics and Photon Science, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea;1. Department of Materials and Metallurgical Engineering, Bangladesh University of Engineering and Technology, Dhaka 1000, Bangladesh;2. Department of Chemistry, Dhaka Commerce College, Dhaka, Bangladesh;1. Joan & Sanford I. Weill Medical College of Cornell University, New York, New York;2. Division of Gastroenterology and Hepatology, New York-Presbyterian Hospital/Weill Cornell Medicine, New York, New York |
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| Abstract: | The release of endogenous 5-hydroxytryptamine (5-HT) from the in vitro incubated neurointermediate lobe (NIL) of the rat hypophysis was measured by HPLC with electrochemical detection. 5-HT release evoked by electrical stimulation of the pituitary stalk from the NIL, but not from the isolated neural lobe (NL) was enhanced in the presence of the dopamine receptor antagonist sulpiride (1 microM). The opiate receptor antagonist naloxone (1 microM) had no effect on the evoked release of 5-HT from the NIL or NL. In conclusion, the release of endogenous 5-HT from the intermediate lobe is under inhibitory control of endogenous dopamine. |
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