The chronotropic effect of acetylcholine in the presence of vecuronium and atracurium A study in the isolated perfused rabbit heart |
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| Authors: | D J BELLIS S DAY P K BARNES |
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| Institution: | Magill Department of Anaesthetics, Westminster Hospital, London. |
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| Abstract: | The bradycardia produced by 1 microgram acetylcholine in the isolated perfused rabbit heart, in the presence of vecuronium and atracurium, was studied and compared with control. Vecuronium at a concentration of 2.5 micrograms/litre and atracurium 6 micrograms/litre did not enhance the negative chronotropic effect of acetylcholine. Atracurium produced a statistically significant inhibition of the negative chronotropic effect of acetylcholine. |
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| Keywords: | Neuromuscular relaxants atracurium vecuronium Heart arrhythmia bradycardia |
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