Perfusion of rat colon with sennosides, rhein and rheinanthrone. Concentration-related histamine release. |
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| Authors: | G Autore G Caliendo A Pepe F Capasso |
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| Affiliation: | Department of Experimental Pharmacology, Via Domenico Montesano 49, Naples, Italy. |
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| Abstract: | Rat colon perfused intraluminally in vitro and in vivo released histamine into the perfusates. Histamine release was increased by rhein 0.1-10 micrograms/ml and much more by rheinanthrone 0.1-10 micrograms/ml but not by sennosides A or B 1-10 micrograms/ml. The effect of rhein and rheinanthrone was reduced by tritoqualine 20 mg/kg. This raises the possibility that laxation by senna and its derivatives involves histamine formation. |
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