| 细胞因子对视网膜神经元保护和诱导作用的研究进展 |
| |
| 作者姓名： | Zheng H Li GL |
| |
| 作者单位： | 100730,首都医科大学北京同仁眼科中心 |
| |
| 摘 要： | 近年来细胞因子在视网膜功能重建中的作用已初见端倪。研究发现,脑源性神经营养因子、睫状神经营养因子、碱性成纤维细胞生长因子及神经营养素4可以防止视网膜光感受器细胞变性的发生,增强光感受器细胞损伤后的修复,促进视网膜神经节细胞的发育,刺激神经节细胞轴突的再生。同时,晶状体上皮源性生长因子及人羊膜上皮细胞分泌的细胞因子也对神经节细胞有保护效应。而神经营养素-3在视网膜的作用性质还有待更多的研究。（中华眼科杂志,2005,41：861-864）
|
| 关 键 词： | 细胞因子 视网膜神经元 保护作用 诱导作用 光感受器 睫状神经营养因子 |
| 收稿时间： | 04 14 2005 12:00AM |
| 修稿时间： | 2005-04-14 |
Advances in researches for protection and induction of cytokines to retinal neurons |
| |
| Zheng H,Li GL.Advances in researches for protection and induction of cytokines to retinal neurons[J].Chinese Journal of Ophthalmology,2005,41(9):861-864. |
| |
| Authors: | Zheng Hao Li Gen-lin |
| |
| Institution: | Beijing Tongren Eye Center, Capital University of Medical Sciences, Beijing 100730,China |
| |
| Abstract: | The role of cytokines in retinal functional reconstruction has been studied extensively. It has been found that brain derived neurotrophic factor (BDNF),ciliary neurotrophic factor (CNTF), basic fibroblast growth factor(bFGF) and neurotrophin-4(NT-4) can not only prevent retinal photoreceptor cells(RPCs) from degeneration and improve RPCs recovery after being damaged, but also promote growth and development of retinal ganglion cells(RGCs) and stimulate regeneration of axons of RGCs. Furthermore, it has been found that lens epithelium-derived growth factor (LEDGF) and human amniotic epithelial cells(HAECs) both have effects of protection on RGCs, but the role of neurotrophin-3(NT-3) in retina will be studied in the future. |
| |
| Keywords: | Cytokines Nerve growth factors Retina Photoreceptors Transplantation |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
|
