COX-2、VEGF在子宫内膜癌中的表达及意义

目的 探讨环氧化酶-2（COX-2）和血管内皮生长因子（VEGF）在子宫内膜癌发生发展中的作用。方法 采用免疫组化SP法检测41例子宫内膜癌和15例正常子宫内膜组织中COX-2、VEGF的表达。结果 子宫内膜癌组织中COX-2、VEGF的阳性表达率明显高于正常子宫内膜组织（P均〈0．05，）；低分化和肌层浸润〉1／2者的子宫内膜癌组织中COX-2表达明显高于中、高分化和肌层浸润≤1／2（P〈0．05）者；COX-2表达阳性的子宫内膜癌，其VEGF阳性率明显高于COX-2表达阴性者（P〈0．05）。结论 COX-2在子宫内膜癌组织中呈高表达，并可上调VEGF的表达，二者可能与子宫内膜癌的发生发展有关。

Expression and significance of cyclooxygenase-2 and vascular endothlial cell growth factor in endometrial carcinoma

Objective:To investigate the effect of cyclooxygenase-2(COX-2)and vascular endothelial cell growth factor(VEGF)in endometrial carcinoma.Method:The expression of COX-2 and VEGF were examined by immunohistochemistry SP method in 41 cases of endometrial carcinoma and 15 cases of normal endometrium.Re-sults:The expression of COX-2,VEGF was significantly higher in endometrial carcinoma than in normal endometrium(P<0.05).Overexpression of COX-2 in endometrial carcinoma was related to differentiation degree and depth of invasion(P<0.05),but had no relation to FIGO staging(P>0.05).The expression of VEGF was significantly higher in cases whose COX-2 expressed positively than COX-2 expressed negatively(P<0.05).Conclusion:COX-2 and VEGF are closely related with carcinogenesis and development of endometrial carcinoma.COX-2 may induce the expression of VEGF.