815例不稳定型心绞痛中医证候的因子分析

目的：探讨不稳定型心绞痛（unstable angina,UA）中医证候规律,并初步建立证候诊断标准。方法：多中心前瞻性收集815例经冠状动脉造影证实的UA患者,采用因子分析对其四诊信息进行中医证候非线性降维研究。结果：在提取的5个公因子中,F1为心肾阴虚,F2为心脾两虚,F3为痰瘀互阻,F4为气虚血瘀,F5为阳虚寒凝。其中以F4气虚血瘀所占比例最大,并且初步建立了各个证候的诊断条件。结论：气虚血瘀是UA的核心病机。因子分析能够帮助进行中医证候的分类研究和初步建立证候诊断标准。

Factor analysis of traditional Chinese medicine syndromes in 815 patients with unstable angina

Objective: To explore the laws of traditional Chinese medicine (TCM) syndromes in unstable angina, and to establish the preliminary diagnostic criteria for TCM syndromes.Methods: Multi-center prospective research on TCM syndromes in 815 cases of unstable angina was done with the nonlinear dimension reduction by factor analysis.Results: There were five extracted factors in factor analysis: F1, F2, F3, F4 and F5. F1 was yin deficiency of heart and kidney, F2 was deficiency of both heart and spleen, F3 was intermingled phlegm and blood stasis, F4 was qi deficiency and blood stasis, and F5 was yang deficiency and coagulated cold. Qi deficiency and blood stasis (F4) syndrome accounted for the maximum proportion. The diagnostic criteria for TCM syndromes were preliminarily and respectively established.Conclusion: Qi deficiency and blood stasis is the key factor of pathogenesis. The factor analysis can help us classify traditional Chinese medicine syndromes and establish the preliminary diagnostic criteria.