| XPC基因Ala499Val和Lys939Gln多态与癌症发病风险关联的meta分析 |
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| 引用本文： | 张佳鑫,钟逾,邵敏华,钱吉,范薇薇,卢大儒.XPC基因Ala499Val和Lys939Gln多态与癌症发病风险关联的meta分析[J].中国优生优育,2008,14(4). |
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| 作者姓名： | 张佳鑫 钟逾 邵敏华 钱吉 范薇薇 卢大儒 |
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| 作者单位： | 复旦大学生命科学学院遗传工程国家重点实验室和现代人类学教育部重点实验室 |
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| 摘 要： | 目的 为更清楚地了解NER通路上的XPC基因多态性与癌症发病风险的关联.方法 利用所有已发表的相关病例-对照研究对两个重要单核苷酸多态性位点:Ala499Val 和Lys939Gln进行了meta-分析.结果 Ala499Val位点的总体分析发现,499TT基因型的个体比499CT及499CC基因型个体,其癌症发病风险高25%(OR = 1.25,95% CI =1.09-1.44);499CT杂合基因型个体的癌症发病风险较纯合基因型个体低10% (OR = 0.90,95%CI = 0.84-0.97).Lys939Gln位点的总体分析发现,939CC基因型的个体比939CA与939AA基因型个体的癌症发病风险略高8% (OR = 1.08,95%CI = 1.00-1.16).此外,依据癌症种类和人群的不同对两个位点的亚组分析结果发现,Lys939Gln位点在高加索人群中与癌症发病风险显著相关.结论 499T和939C均为风险性的等位基因.499TT或939CC基因型的个体、尤其是939CC基因型的高加索人,有更高的癌症发生的可能性.
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| 关 键 词： | meta分析 癌症风险 |
The association of XPC Ala499Val and Lys939Gln polymorphisms with cancer risk:a meta-analysis |
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| ZHANG Jia-xin,ZHONG Yu,SHAO Min-hua,QIAN Ji,FAN Wei-wei,LU Da-ru.The association of XPC Ala499Val and Lys939Gln polymorphisms with cancer risk:a meta-analysis[J].Journal of Improving Birth Outcome and Child Development of China,2008,14(4). |
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| Authors: | ZHANG Jia-xin ZHONG Yu SHAO Min-hua QIAN Ji FAN Wei-wei LU Da-ru |
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| Abstract: | Objective and Methods In order to clarify the association between the two polymorphisms:Ala499Val and Lys939Gln in XPC in NER pathway and cancer risk,we performed a meta-analysis from all eligible case-control studies.Results The results showed that individuals with the 499TT genotype showed a 25%(OR = 1.25,95% confidence interval(CI)= 1.09-1.44)increased cancer risk compared with individuals with the 499CT/499CC genotype;On the other hand,individuals with the 499CT genotype was associated with a 10%(OR = 0... |
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| Keywords: | XPC SNP |
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