| 银屑病患者皮损中血管内皮生长因子和基质金属蛋白酶2的表达 |
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| 引用本文： | 何秋波,李红文,于建斌. 银屑病患者皮损中血管内皮生长因子和基质金属蛋白酶2的表达[J]. 中华皮肤科杂志, 2004, 37(7): 398-399 |
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| 作者姓名： | 何秋波 李红文 于建斌 |
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| 作者单位： | 1. 郑州大学第一附属医院皮肤科2. 郑州大学附属第一医院皮肤科 |
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| 基金项目： | 河南省科技厅科研基金项目资助(20004025200) |
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| 摘 要： | 目的探讨血管内皮生长因子(VEGF)、基质金属蛋白酶2(MMP-2)在寻常性银屑病皮损血管生成中的作用。方法采用免疫组化法检测30例寻常性银屑病皮损、12例非皮损和12例正常人皮肤中VEGF、MMP-2的表达水平与分布特征。结果①VEGF在银屑病皮损组织中阳性表达明显高于非皮损组织和正常人皮肤(P<0.05)。②MMP-2在银屑病皮损组织中的阳性表达明显高于非皮损组织和正常人皮肤(P<0.05)。③VEGF、MMP-2在银屑病皮损中表达呈正相关(P<0.05)。结论VEGF、MMP-2在寻常性银屑病发病的血管生成中可能起协同作用。
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| 关 键 词： | 银屑病 血管内皮生长因子 基质金属蛋白酶2 血管生成 免疫组化 发病机制 |
| 收稿时间： | 2003-11-03 |
| 修稿时间： | 2003-11-03 |
Expression of Vascular Endothelial Growth Factor and Matrix Metalloproteinase 2 in Psoriatic Lesions |
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| HE Qiu-bo,LI Hong-wen,YU Jian-bin. Expression of Vascular Endothelial Growth Factor and Matrix Metalloproteinase 2 in Psoriatic Lesions[J]. Chinese Journal of Dermatology, 2004, 37(7): 398-399 |
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| Authors: | HE Qiu-bo LI Hong-wen YU Jian-bin |
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| Affiliation: | HE Qiu-bo,LI Hong-wen,YU Jian-bin. Department of Dermatology,First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China |
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| Abstract: | Objective To study the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase 2 (MMP-2) in psoriatic lesions. Methods Immunohistochemistry was used to detect the expression of VEGF and MMP-2 in the skin lesions, non-lesional skin and the skin of normal controls. Results The expression of VEGF and MMP-2 was significantly higher in the lesional skin than that in non-lesional skin and normal controls(P < 0.05). There was a positive correlation between the expression of VEGF and MMP-2 in the skin lesions. Conclusion Overexpression of VEGF and MMP-2 in psoriatic lesions may contribute to the pathogenesis of the psoriasis. |
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| Keywords: | Psoriasis Endothelial growth factors Gelatinase A |
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