| 5-氟尿嘧啶-壳聚糖微囊体外释放度测定方法的建立 |
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| 引用本文： | 金邻豫,白颖,赵辉,许秋菊,王玮.5-氟尿嘧啶-壳聚糖微囊体外释放度测定方法的建立[J].河南大学学报(医学版),2010,29(4). |
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| 作者姓名： | 金邻豫 白颖 赵辉 许秋菊 王玮 |
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| 作者单位： | 1. 河南大学化学化工学院,仿真实验室,河南,开封,475004
2. 河南大学药学院,药剂学教研室,河南,开封,475004 |
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| 摘 要： | 目的:建立5-氟尿嘧啶-壳聚糖微囊体外释放度测定的方法。方法:通过紫外全波长扫描确定5-氟尿嘧啶最大吸收波长,以紫外分光光度法测定其含量,以直接释药法测定其体外释放度,同时进行了方法学考察。结果:5-氟尿嘧啶-壳聚糖微囊体外释药量在6～14 mg/L浓度范围内线性关系良好,平均回收率为100.69%,RSD为0.95%。结论:所建立的方法简单、方便、准确,适合于5-氟尿嘧啶-壳聚糖微囊体外释放度的测定。
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| 关 键 词： | 5-fu 壳聚糖微囊 体外释放 方法 |
Establishing a method for the determination of 5-fu- microcapsules release rate in vitro |
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| JIN Lin-yu,BAI Ying,ZHAO Hui,XU Qiu-ju,WANG Wei.Establishing a method for the determination of 5-fu- microcapsules release rate in vitro[J].Journal of Henan University,2010,29(4). |
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| Authors: | JIN Lin-yu BAI Ying ZHAO Hui XU Qiu-ju WANG Wei |
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| Abstract: | Objective: To establish a detecting method for 5 fu microcapsules release rate in vitro.Methods: The longest absorb wave of 5 fu was scanned by ultraviolet whole wave length,its contents were determined by the ultraviolet spectrophotometry.The direct release method was used to test the microcapsules release degree in vitro,and examined by methodology.Results: The 5 fu microcapsules release rate in vitro had the better linear relation at the range of 6～14 mg/L.The average recovery was 100.69%,RSD was 0.95%.Conclusion: The method established is simple,convenient and accurate which is fitted for the determination of 5-fu-chitosan microcapsules release rate in vitro. |
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| Keywords: | 5-fu chitosan microcapsules release in vitro method |
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