SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma |
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| Authors: | Wrench David Leighton Pamela Skibola Christine F Conde Lucia Cazier Jean-Baptiste Matthews Janet Iqbal Sameena Carlotti Emanuela Bödör Csaba Montoto Silvia Calaminici Maria Gribben John G Lister T Andrew Fitzgibbon Jude |
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| Affiliation: | Centre for Haemato-Oncology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. d.j.wrench@qmul.ac.uk |
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| Abstract: | Inherited risk determinants for follicular lymphoma (FL) have recently been described in the immune gene-rich human leukocyte antigen region on chromosome 6p. The known importance of host immune response to FL survival led us to evaluate these germline factors in FL outcome. We confirm the association of single nucleotide polymorphisms rs10484561 (P = 3.5 × 10??) and rs6457327 (P = .008) with risk of FL and demonstrate that rs6457327 predicts both time to (P = .02) and risk of (P < .01) FL transformation independently of clinical variables, including the Follicular Lymphoma International Prognostic Index. |
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