烧伤早期血清CRP,C3,Tf,PA变化及临床意义

为探索烧伤早期血清急性期蛋白的变化规律及其临床意义，将３２例烧伤病人按烧伤总面积大小分为小于２０％，２０％～５０％和大于５０％三组，于伤后８，２４，４７，７２小时采血，组３加测伤后，７，１４，２１天三个时相点以观察与感染的关系，以免疫速率散射浊度法测定ＣＲＰ，Ｃ３，Ｔｆ用琼脂扩散法，ＰＡ用火箭免疫电泳法测定，结果表明：伤后４８～７２小时血清ＣＲＰ达到高峰（Ｐ〈０．０１）；伤后８小时Ｃ３显著下降（Ｐ

The changes and clinical significance of serum CRP, C3, Tf, and PA in the early postburn stage]

The aim of this study was to investigate the regulation and clinical significance of serum acute phase proteins. The patients were divided into three groups: group I consisted of 11 patients with less than 20% of TBSA; group II 10 patients with 20-50% of TBSA and group III 11 patients with more than 50% of TBSA. Blood samples were taken at 8, 24, 48 and 72 h postburn, and in group III additional blood samples were taken on the 7th, 14th, 21st day or in septic episode. The concentration of CRP and C3, Tf, PA were detected by rate nephelometry, agar immunodiffusion and rocket immunoelectrophoresis respectively. Compared with controls, the peak value of CRP was observed during 48-72 h (P < 0.01), C3 decreased at 8 h and lowest at 24 h. Tf was lowered at 48 h, PA and Tf shared the similar changes. However, all four variables had no marked difference during infection and sepsis. The results showed no correlation between C3 and CRP (r = 0.0885, P > 0.05). The results suggested that: 1. CRP mainly reflected the extent of injury but not sepsis; 2. increased CRP was not the causative factor of decreased C3. Tf reduction accelerated bacterial growth.