SD—Zn或SD—Ag涂抹创面与切痂植皮时机对放烧复合伤大…

采用６Ｇｙ照射复合１５％Ⅲ度烧伤模式，探讨了ＳＤ－Ｚｎ或ＳＤ－Ａｇ涂抹创面与切痂植皮时机对复合伤大鼠的疗效作用，结果表明伤后ＳＤ－Ｚｎ或ＳＤ－Ａｇ涂抹创面并于１５天后切痂植皮及单用ＳＤ－Ｚｎ涂抹组，伤后１５天存活率分别为６３％，６９％和７５％，均高于对照组（４２％），创面面积缩小速度明显加快，血细胞数也低于对照，用ＳＤ－Ｚｎ涂抹后７天植皮组，术后２０天内动物全部死亡，而１５天后植皮者术后动物全部存

Effects of locally used SD zinc, SD silver and skin transplantation on the combined radiation-burn injury in the rat]

Effects of local use of sulfadiazine (SD) zinc, SD silver in the wound and skin transplantation on the combined injury of 6 Gy radiation and 15% TBSA burn were investigated in the present study. In the three groups of SD zinc or SD silver plus skin grafting at 15 d after combined injury and SD zinc alone, the 15-day survival rates were 63%, 69% and 75% respectively, and significantly higher than that of control group (42%). The repair time of burn wound was shorter and the number of white blood cells was lower than that of control. Animals in the group of local use of SD silver followed by skin grafting on the 7th day all died, but all of the animals survived when the skin grafting was performed after 15 days. These results suggested that SD zinc and SD silver showed some therapeutic effects on the combined radiation-burn injury. In critical phase of the combined injury, surgical operation should be prohibited. However, in the recovery phase, skin transplantation could be performed.