| Abstract: | The influence of oxametacine, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-3-indoyl]acetohydroxamic acid, a new non-steroidal anti-inflammatory drug, on prostaglandin-synthetase was studied in vitro on rat spleen tissue. The drug exerts an inhibitory effect on prostaglandin biosynthesis which closely mimics that of indomethacin. On the other hand, oxametacine proves more active than other non-steroidal anti-inflammatory agents, namely ketoprofen, flufenamic acid, phenylbutazone and acetylsalicylic acid. |
