基于人群的宫颈癌及癌前病变危险因素调查

目的研究自然人群宫颈癌相关危险因素。方法在深圳及周边10000名女性宫颈癌筛查基础上进行危险因素调查。结果各项检测结果齐全者8556例,平均年龄38.9岁。高载量HPV感染及HPV-16、58、31、18、33和HPV-52亚型感染患癌风险高;45～59岁年龄段、人工流产≥3次、经阴道分娩≥3次,有家中分娩史者为患CIN2＋的危险因素;而受教育程度高、初潮年龄小、与现在性伴侣性生活时间长、使用避孕套避孕和曾在医院体检为保护性因素。多因素非条件Logistic回归分析,仅HPV感染和曾在医院体检有统计学意义。结论高HPV病毒载量及某些高危亚型具有更强致癌性;定期筛查HPV感染所致宫颈癌前病变及阻断病变的进展是防治宫颈癌的有效手段。

A survey of relevant factors for cervical cancer and high grade cervical lesion based on population

Objective To investigate the relvant risk factors of cervical cancer in natural population.Methods A total of 10 000women in Shenzhen and around areas were included to screen cervical cancer.Each subject was interviewed with a risk factor questionnaire.Results There were 8 556cases with complated data with the average age of 38.9years old.High HPV loads and subtypes such as HPV-16 , -58 , -31 , -18 , -33and HPV-52infection were high risk factors of cervical cancer.Aged 45～59ys , vaginal delivery more than 3times , abortion more than 3times and delivery at home were risk factors for CIN2+ , while high level education , early menarche , long time living with current sexual partner , condom use as contraception and medical care in hospital were protective factors.Conclusions High HPV loads and some high risk subtypes were more carcinogenic.Regularly screening precancerous lesion accounting for HPV infection and blocking the progress of cervical lesion is effective method for preventing cervical cancer.