Association of Pasteurella multocida toxin with vimentin |
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| Authors: | Shime Hiroaki Ohnishi Takahiro Nagao Kaori Oka Kiyomasa Takao Toshifumi Horiguchi Yasuhiko |
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| Institution: | Department of Bacterial Toxinology, Research Institute for Microbial Diseases. Research Center for Structural and Functional Proteomics, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan. |
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| Abstract: | To help understand the molecular mechanisms of Pasteurella multocida toxin (PMT) action, we searched for a cellular protein interacting with PMT. The ligand overlay assay revealed a 60-kDa cellular protein that binds to a region from the 840th to 985th amino acids of the toxin. This protein was identified as vimentin by peptide mass fingerprinting. The N-terminal head domain of vimentin was further found to be responsible for the binding to the toxin. |
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