Stress increases noradrenaline release in the rat frontal cortex: prevention by diazepam |
| |
| Authors: | Z L Rossetti C Portas L Pani S Carboni G L Gessa |
| |
| Affiliation: | 'B.B. Brodie' Department of Neuroscience, University of Cagliari, Italy. |
| |
| Abstract: | Foot-shock produced a more than 2-fold increase in noradrenaline (NA) release from the frontal cortex of freely moving rats. The effect of acute stress was almost completely prevented by the administration of diazepam (5 mg/kg i.p.). Diazepam alone inhibited cortical NA release, the maximal inhibition (-57%) being observed 90 min after the injection. Cortical NA release therefore appears to be a reliable index of central noradrenergic activity in response to stressful conditions. |
| |
| Keywords: | |
|
