Effect of chlorophos (dipterex,trichlorphon) on high-threshold potassium and calcium channels of the neuronal membrane |
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Authors: | Yu V Bukanova E I Solntseva |
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Institution: | (1) Laboratory of Functional Synaptology, Moscow;(2) Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow |
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Abstract: | The effect of chlorophos (dipterex, trichlorphon) on high-threshold potassium and calcium currents is studied on isolated
snail neurons using the patch-clamp technique. Chlorophos (10–1000 μmol/liter) is found to reversibly lower the peak amplitude
of a high-threshold potassium current by 30% on average and exerts two independent effects on a high-threshold calcium current:
reversible lowering of the peak amplitude by 35% on average and, in 30% of cases, reversible inhibition of its activation,
inactivation, and deactivation. this effect is abolished by adding diltiazem (a calcium channel antagonist) in a concentration
of 100 μmol/liter to the medium.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
1, pp. 59–62, January, 1996
Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences |
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Keywords: | insecticides chlorophos potassium channels calcium channels snail neurons |
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