星形细胞瘤周水肿区CD105、VEGF的表达及意义

目的:探讨CD105及VEGF在星形细胞瘤周水肿区表达情况及临床意义。方法:星形细胞瘤患者51例,依据其术前MRI T2WI序列图像将瘤周水肿分为3度,术中取对应水肿组织后行CD105及VEGF免疫组化染色,计算微血管密度(MVD),并分析其表达水平与水肿程度的关系;正常脑组织标本9例为对照。结果:正常脑组织无CD105及VEGF表达;瘤周水肿区CD105-MVD与水肿分度正相关(r=0.997,P<0.05);VEGF表达与CD105-MVD正相关(r=0.923,P<0.05),同时与水肿分度正相关(r=0.929,P<0.05)。结论:瘤周VEGF表达和持续存在可能是促进CD105阳性微血管的形成,进而造成血管源性瘤周水肿的始动因素。水肿区大量CD105标记新生血管出现提示该区可能是瘤细胞易于发生浸润的区域。

Expression of CD105 and VEGF in Edematus Areas of Human Astrocytomas

Objective: To study the expression of CD105 and VEGF in the edematus areas around human astrocytomas and analyze its clinical significance.Methods: Fifty-one cases with astrocytomas and nine normal controls were recruited.According to their data of T2WI,the degree of brain edema was categorized into 3 grades.The expression of CD105 and VEGF in the edematous areas around astrocytomas were detected by immunohistochemical staining.The microvessel density(MVD) was calculated and the relation between CD105-MVD,VEGF and degree of edema was analyzed.Results: No CD105 or VEGF was detected in normal brain tissue.In cases with astrocytomas,CD105-MVD was positively related to the degree of brain edema(r=0.997,P<0.05),the expression of VEGF was positively related to CD105-MVD and the degree of brain edema(r=0.923,r=0.929,P<0.05).Conclusion: The expression of VEGF may promote the expression of CD105(+) microvessels,which contribute to the vasogenic brain edema around astrocytomas.The edematous area may be invaded by astrocytomas easily due to large number of new blood vessels marked by CD105.