荧光原位杂交技术对膀胱癌尿脱落细胞诊断价值的荟萃分析

目的通过荟萃分析比较荧光原位杂交技术（fluorescence in situ hybridization，FISH）和细胞学检测膀胱癌尿脱落细胞的灵敏度和特异度。方法从中国生物医学文献数据库、PubMed等专业数据库中收录的有关FISH、细胞学与膀胱癌尿脱落细胞检测相关分析文献中，纳入符合条件的文献，应用Revman5．0进行荟萃分析。结果HSH用于诊断膀胱癌尿脱落细胞的灵敏度为78．1％（0R值为4．98，95％CJ：3．63～6．83），显著优于细胞学的46．3％（P〈0．00001）；HSH检查的特异度为93．9％（OR值为0．41，95％CI：0．193-0．930），稍低于细胞学检查的96．3％（P=0．03）。结论荟萃分析肯定了FISH用于膀胱癌尿脱落细胞检测的价值，其灵敏度高，特异度接近细胞学检查。

A meta-analysis of diagnostic value of FISH in detection of urine exfoliated cells in bladder cancer

Objective To assess the sensitivity and specficity of fluorescence in situ hybridiza- tion （FISH） in detection of urine exfoliated cells in bladder cancer. Methods The randomized controlled trials comparing sensitivriy and specificity of FISH with cytology in detection of urine ex- foliated cells in bladder cancer from PubMed and China Biological Medicine Databases. Meta-analysis was performed by combining the odd ratios （OR） of the individual studies with random response model. Results The recta-analysis results showed that the sensitivity of FISH was 78. 1% （OR： 4.98,95%CI：3.63-6.83） and cytology was 46.3% in diagnosis of bladder cancer, the difference was significant （P〈0. 000 01）. The specificity of cytology （96.3%） was higher than that in FISH （93.9%）（OR：0.41,95 aft0 CI：0. 193-0. 930） ,P=0.03. Conclusions Meta-analysis results con- firmed the value of FISH in detection of bladder cancer.