盐酸多柔比星脂质体注射液药效学研究 |
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引用本文: | 王荣端,张莉,李彦辉,张兰,魏娜. 盐酸多柔比星脂质体注射液药效学研究[J]. 河北医药, 2009, 31(21) |
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作者姓名: | 王荣端 张莉 李彦辉 张兰 魏娜 |
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作者单位: | 1. 石药集团中奇制药技术(石家庄)有限公司,河北省制剂工程技术研究中心,石家庄市,050051 2. 石药集团中奇制药技术,石家庄,有限公司,河北省制剂工程技术研究中心,石家庄市,050051 |
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摘 要: | 目的比较盐酸多柔比星脂质体注射液与市售楷莱注射液的体内抗肿瘤作用。方法建立小鼠实体型S180肿瘤模型、小鼠腹水型S180、L1210肿瘤模型和静脉注射L1210的小鼠肝转移模型,探讨盐酸多柔比星脂质体与市售楷莱注射液的抗肿瘤作用。结果盐酸多柔比星脂质体注射液与市售楷莱注射液单次以16.0mg/kg静脉注射,对小鼠S180实体型的抑瘤率分别为95.4%和87.9%,二者差异无统计学意义(P>0.05);单次以8.0和12.0mg/kg静脉注射,仅盐酸多柔比星脂质体注射液12.0mg/kg对腹水型S180小鼠有治疗作用,且疗效明显优于市售楷莱注射液组(P<0.05);单次以8.0和12.0mg/kg静脉注射,与空白组相比均可显著延长腹水型L1210肿瘤模型和肝转移模型小鼠的生存时间,二者差异无统计学意义(P>0.05),但与等剂量的盐酸多柔比星注射液组比较差异有统计学意义(P<0.05)。结论相同给药剂量下,盐酸多柔比星脂质体注射液的体内抗肿瘤作用与市售楷莱注射液等效,并显著优于盐酸多柔比星注射液。
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关 键 词: | 多柔比星 脂质体 抗肿瘤药 |
Studies on the anti-tumor effect of liposomal doxorubicin hydrochloride injection |
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Affiliation: | WANG Rongduan; ZHANG Li; LI Yanhui; et al.Zhongqi Pharmaceutical Technology(Shijiazhuang)Co.; Ltd; Shijiazhuang 050051; China; |
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Abstract: | Objective To compare the anti-tumor efficacy between liposomal doxorubicin hydrochloride and CAELYX injection.Methods The antineoplastic effects of liposomal doxorubicin hydrochloride and CAELYX injection were evaluated by using mice's transplabted solid tumor S180,S180 ascitic,L1210 ascitic and liver metastasis tumor models.Results After a single intravenous injection at a dose level of 16mg/kg,the inhibition rate of tumor of liposomal doxorubicin hydrochloride and CAELYX injection were were 95.4% and 87.9... |
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Keywords: | doxorubicin hydrochloride liposome anti-tumor drugs |
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