特女贞苷与红景天苷的大鼠在体胃肠吸收比较

特女贞苷与红景天苷是女贞子炮制前后含量变化较大的2种活性成分。为探讨女贞子炮制增效机制，该实验采用大鼠在体胃肠灌流模型，用HPLC测定给药后不同时间点大鼠胃与小肠灌流流出液中特女贞苷与红景天苷含量并计算吸收速率常数和吸收百分率，结果在特女贞苷的胃肠灌流流出液中均可检出其次级苷红景天苷。特女贞苷与红景天苷在小肠中的吸收速率常数分别为0.055 3，0.144 2 h^-1，4 h累计吸收率分别为24.46%，60.14%，在胃中吸收速率常数分别为5.70，8.26 h^-1，4 h累计吸收率分别为34.21%，47.23%。实验证明特女贞苷在大鼠胃与小肠内均可被代谢为红景天苷，红景天苷较特女贞苷更利于胃肠吸收。结果提示女贞子炮制后补肝肾药效增强与特女贞苷转化为红景天苷后更利于机体吸收有关。

Comparation of gastrointestinal absorption studies of specnuezhenide with salidroside in rats

The experiment was designed to study the mechanism of increasing efficiency of Ligustrum lucidum steamed with wine. Rats in vivo with gastrointestinal perfusion model were used. The contents of salidroside and specnuezhenide in the fluid of gastrointestinal perfusion of rats were measured by HPLC at different time points after dosing. Then the K_a and absorption percentage were calculated. Specnuezhenide could be detected in the fluid of gastrointestinal perfusion of specnuezhenide. The K_a of the specnuezhenide and salidroside in the fetal intestines are 0.055 3 and 0.144 2 h^-1 respectively and the total absorptivity are 24.46% and 60.14% respectively after 4 hours. The K_a in the stomach are 5.70 and 8.26 h^-1 respectively and the total absorptivity are 34.21% and 47.23% respectively after 4 hours. The experiment proved that specnuezhenide can be metabolized into salidroside which is more beneficial for gastrointestinal absorption. The experiment proved that specnuezhenide can be metabolized into salidroside both in the rat's stomach and the fetal intestine and compared with the specnuezhenide salidroside is more conducive to gastrointestinal absorption. The results suggested that the increasing efficiency on liver and kidney of L. lucidum steamed with wine has business with the fact that Specnuezhe nide is more conducive to the body after it is changed into salidroside.