| 非水电位滴定法测定氢溴酸西酞普兰原料药含量的改进 |
| |
| 引用本文： | 胡猛慎,洪志玲,黄剑英,李玲玲.非水电位滴定法测定氢溴酸西酞普兰原料药含量的改进[J].中国现代应用药学,2014,31(3):323-325. |
| |
| 作者姓名： | 胡猛慎 洪志玲 黄剑英 李玲玲 |
| |
| 作者单位： | 厦门市药品检验所,厦门市药品检验所,厦门市药品检验所,厦门市药品检验所 |
| |
| 基金项目： | 厦门市科技平台(3502Z20121035) |
| |
| 摘 要： | 目的建立革除汞盐的非水电位滴定法测定氢溴酸西酞普兰原料药的含量。方法采用以冰醋酸-醋酐（1：5）为溶剂的高氯酸电位滴定法测定氢溴酸西酞普兰原料药的含量。结果成功革除醋酸汞，所得实验结果与原方法的测定结果基本一致。结论建立的方法革除了汞盐试剂，滴定突越明显，方法简便、准确，适于氢溴酸西酞普兰原料药的含量测定。
|
| 关 键 词： | 非水电位滴定 革除汞盐 氢溴酸西酞普兰 |
| 收稿时间： | 2013/8/28 0:00:00 |
| 修稿时间： | 2013/12/5 0:00:00 |
Optimization of Determination Method of Citalopram Hydrobromide by Non-aqueous Potentiometric Titration |
| |
| HU Mengshen,HONG Zhiling,HUANG Jianying and LI Lingling.Optimization of Determination Method of Citalopram Hydrobromide by Non-aqueous Potentiometric Titration[J].The Chinese Journal of Modern Applied Pharmacy,2014,31(3):323-325. |
| |
| Authors: | HU Mengshen HONG Zhiling HUANG Jianying and LI Lingling |
| |
| Institution: | Xiamen Institute for Drug Control,Xiamen Institute for Drug Control,Xiamen Institute for Drug Control,Xiamen Institute for Drug Control |
| |
| Abstract: | OBJECTIVE To establish a determination method of citalopram hydrobromide by non-aqueous potentiometric titration without using mercurate. METHODS Non-aqueous potentiometric titration was used for assay. Citalopram hydrobromide was dissolved in glacial acetic acid-acetic anhydride（1 ： 5） instead of mercuric salt. RESULTS The results of the improved method were same with that of the original methods. CONCLUSION The improved method discards mercuric salt and obtain an abrupt change of the titration cruve. It is simple and accurate for the determination of citalopram hydrobromide. |
| |
| Keywords: | Non-aqueous potentiometric titration Discard mercurate Citalopram Hydrobromide |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《中国现代应用药学》浏览原始摘要信息 |
| 点击此处可从《中国现代应用药学》下载免费的PDF全文 |
