| 帕金森病患者红细胞膜脂区流动性和胰岛素受体的变化 |
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| 引用本文： | 何成 潘小平. 帕金森病患者红细胞膜脂区流动性和胰岛素受体的变化[J]. 第二军医大学学报, 1991, 12(3): 218-220 |
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| 作者姓名： | 何成 潘小平 |
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| 作者单位： | 训练部生物化学教研室，上海医科大学基础医学部神经化学研究室，上海医科大学基础医学部神经化学研究室，上海医科大学基础医学部神经化学研究室，上海医科大学基础医学部神经化学研究室，上海市华山医院，上海市华山医院 200433，200032，200032，200032，200032，上海，200040，上海，200040 |
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| 摘 要： |
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| 关 键 词： | 震颤性麻痹 胰岛素 受体 膜脂区 |
Changes of Membrane Fluidity and Insulin Receptor of Erythrocytes in Parkinson Disease |
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| He Cheng,Pan Xiaoping,Lu Zhihong,Zhang Binghai,Wang Deling,Wu Yonglin,Zhang Weiren. Changes of Membrane Fluidity and Insulin Receptor of Erythrocytes in Parkinson Disease[J]. Former Academic Journal of Second Military Medical University, 1991, 12(3): 218-220 |
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| Authors: | He Cheng Pan Xiaoping Lu Zhihong Zhang Binghai Wang Deling Wu Yonglin Zhang Weiren |
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| Abstract: | The membrane microviscosity and insulin receptor of erythrocytes were determined by fluorescence polarization analysis and insulin radioligand binding assay simultaneously. The patients with Parkinson disease (PD) had increased membrane microviscosity (P<0.01) and decreased insulin receptor sites (P<0.01) as compared with the control group. A significant negative correlation was found between the two parameters (r=-0.6811,P<0.05), suggesting that decreased membrane fluidity might be one of the factors leading to the decrease of insulin receptor sites. The membrane microviscosity of erythrocytes in the rabbits with parkinsonism induced by injecting 6-hydroxydopamine into unilateral substantia nigra was increased significantly (P<0.05). Our results indicate that the functions of erythrocytes seem to be affected by the lesion of substantia nigra. |
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| Keywords: | Parkinson disease membrane microviscosity membrane fluidity insulin receptor |
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