氟比洛芬酯复合小剂量芬太尼用于乳腺肿块切除术后静脉镇痛的临床观察

目的：观察氟比洛芬酯对乳腺肿块切除术后镇痛的影响。方法：60例择期行乳腺肿块切除术患者，随机分为观察组和对照组，每组30例，均采用静脉喉罩全身麻醉，观察组术前应用氟比洛芬酯1 ml/kg缓慢静脉注射，术毕接镇痛泵含氟比洛芬酯50 mg＋芬太尼0.5 mg＋生理盐水共100 mL。对照组术后接镇痛泵含芬太尼1.0 mg＋生理盐水共100 mL。分别记录术后的视觉模拟评分（VAS）（4 h、8 h、12 h、24 h）、不良反应和芬太尼的用量。结果：术后4 h，8 h观察组的VAS评分明显低于对照组，差异有统计学意义（P0.05），芬太尼的用药量情况，观察组明显少于对照组（P〈0.05），不良反应恶心呕吐发生率的情况，观察组明显少于对照组（P〈0.05）。结论：氟比洛芬酯复合小剂量芬太尼用于乳腺肿块切除术后镇痛效果良好，可明显减少芬太尼用量，不良反应发生率减少。

Postoperative Intravenous Analgesia with Flurbiprofen Axeyil Injection Combined with Low Dose Fentanyl in Patients Undergoing Breast Tumor Resection

Objective：To observe analgesic influence flurbiprofen axeyil injection combined with low dose of fentanyl for postoperative analgesia （PCIA）in patients undergoing breast tumor resection. Method：60 patients undergoing general anexthesia were randomly divided into two groups（n=30）, observation group and control group. Observation group was applied flurbiprofen axeyil injection 1 ml/kg through slow intravenous injection before and during surgery. Observation group wes applied Fentanyl 0.5 mg and flurbitrofen axeyil 50 mg till 100 ml in analgesia pump after surgery.Control group wes applied Fentanyl 1.0mg till 100 ml in analgesia pump after surgery. Visual simulation scale（VAS）（at 4,8,12 and 24 hours）,adverse effects and the amount of Fentanyl after surgery were recorded. Result：The VAS score 4 and 8 hours after surgery in observation group was significantly lower than that in control group（P0.05）. The consumption of fentanyl in observation group was significantly less than that in control group（P〈0.05）. The adverse effect in observation group was significantly less than that in control group（P〈0.05）. Conclusion：CIA with flurbiprofen axeyil injection combine with low dose fentanyl in patients undergoing breast tumor resection can achieve satisfactory analgesia and reduce fentanyl dose and its relate adverse effects.