艾司西酞普兰与帕罗西汀治疗老年期抑郁症对照研究

目的比较艾司西酞普兰与帕罗西汀治疗老年期抑郁症的临床效果和安全性。方法选择2011年1月—2012年6月收治的老年期抑郁症患者50例,随机分为艾司西酞普兰组和帕罗西汀组各25例,艾司西酞普兰组给予艾司西酞普兰以5 mg/d为起始剂量,最高剂量20 mg/d;帕罗西汀组给予帕罗西汀以10 mg/d为起始剂量,最高剂量40 mg/d;均晚餐后口服给药1次,疗程6周。使用汉密尔顿抑郁量表评定疗效,不良反应症状量表评定不良反应,分别在治疗前和治疗2、4、6周末各评定1次。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗2周末艾司西酞普兰组评分[(14.5±4.5)分]较帕罗西汀组[(17.2±3.9)分]有明显下降,比较差异有统计学意义(χ2=2.267,P<0.05)。两组总有效率、第4、6周末两组汉密尔顿抑郁量表评分差异均无统计学意义(均P>0.05)。治疗后艾司西酞普兰组不良反应症状量表评分均低于帕罗西汀组,但比较差异均无统计学意义(均P>0.05)。结论艾司西酞普兰是一种安全有效的抗抑郁药物,适合老年患者应用。

Comparative study of escitalopram and paroxetinee for senile depression

Objective To compare the clinical efficacy and safety of escitalopram and paroxetinee in treating senile depression. Methods Fifty patients with senile depression treated from January 2011 to June 2012 were. randomly divided into escitalopram group and paroxet!ne group,25 patients for each group.Escitalopram was given at the initial dose of 5 mg/d with the maximum of 20 mg/d,while paroxetine at the initial close of 10 mg/d with the maximum of 40 mg/d.Both drugs were orally administered after supper for 6 weeks.Clinical efficacy was assessed with Hamilton depression scale（HAMD） and adverse reactions with treatment emergent symptoms scale（TESS） before treatment and on the 2nd,4th,and 6th weekend after treatment.Measurement data were pro- cessed with t-test,count data with X^2 test,the result of P〈0.05 was considered statistically significant.Results On the 2nd week- end after treatment,scores of escitalopram group [ （ 14.5 ± 4.5 ） 分 ] were lowered significantly than those of paroxetinee group [ （17.2 ± 3.9）分 ],which showed significant difference（X^=2.267, P〈0.05）.The effective rate,on the 4th and 6th weekend after treatment,HAMD scores in both groups showed significant differenee（P〉0.05）.After treatment,TESS scores in eseitalopram group were lower than those in paroxetinee group,which showed no significant difference（P〉0.05）.Conclusion Eseitalopram is a safe and effective antidepressant,which is suitable for senile depression.