| HPLC和微生物法测定万古霉素的血药浓度 |
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| 引用本文： | 钱南萍,乔峰,王华,张馨,许静. HPLC和微生物法测定万古霉素的血药浓度[J]. 中国现代应用药学, 2009, 26(11): 937-940 |
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| 作者姓名： | 钱南萍 乔峰 王华 张馨 许静 |
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| 作者单位： | 1.江苏省泰州市人民医院，江苏 泰州 225300；2.南通大学医学院，江苏 南通 210009 |
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| 摘 要： | 目的比较HPLC和微生物法测定万古霉素血药浓度的差异。方法30名病人静脉滴注万古霉素1.0 g，1次·d-1，分别用HPLC和微生物法测定用药前后的血药浓度。结果HPLC法在5.0～80 μg·mL-1浓度内线性关系良好，回收率97.3%～101.6%，日内、日间RSD分别为1.74%～4.06%和1.22%～4.21%；微生物法线性范围在5.0～60 μg·mL-1，回收率：98.2%～100.8%，日内、日间RSD分别为4.22%～5.51%和4.59%～6.49%。结论2种测定方法回收率和精密度均符合要求，测得的血药浓度无显著性差异。
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| 关 键 词： | 复方单硝酸异山梨酯缓释片；5-单硝酸异山梨酯；水杨酸；阿司匹林；药代动力学；气相色谱法；高效液相色谱法 |
| 收稿时间： | 1900-01-01 |
Comparison between HPLC and Microbiological Method for Determination of the Content of Vancomycin in Human Serum |
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| QIAN Nanping,QIAO Feng,WANG Hu,ZHANG Xin,XU Jing. Comparison between HPLC and Microbiological Method for Determination of the Content of Vancomycin in Human Serum[J]. The Chinese Journal of Modern Applied Pharmacy, 2009, 26(11): 937-940 |
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| Authors: | QIAN Nanping QIAO Feng WANG Hu ZHANG Xin XU Jing |
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| Affiliation: | 1.The PeopLe's HospitaL of Taizhou Jiangsu, Taizhou 225300, China; 2.MedicaL CoLLege of Nantong University, Nantong 226000, China |
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| Abstract: | OBJECTIVE To establish the determination methods of compound isosorbide mononitrate sustained release tablet in human plasma. METHODS The plasma concentration of 5-isosorbide mononitrate and salicylic acid were determined by GC and HPLC method respectivel |
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| Keywords: | compound isosorbide mononitrate sustained release tablet 5-isosorbide mononitrate salicylic acid aspirin pharmacokinetics GC HPLC |
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