The effects of tramadol on hepatic ischemia/reperfusion injury in rats |
| |
| Authors: | Mona F. Mahmoud Samar Gamal Mohamed A. Shaheen Hassan M. El-Fayoumi |
| |
| Affiliation: | Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt;1Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt |
| |
| Abstract: | Objectives:Tramadol is a centrally acting synthetic analgesic. It has a cardioprotective effect against myocardial ischemia-reperfusion (I/R) injury in isolated rat heart. We hypothesized that tramadol may exert a similar protective effect on hepatic I/R injury. Hence, the current investigation was designed to study the possible protective effects of tramadol on experimentally-induced hepatic I/R injury in rats.Results:Tramadol attenuated hepatic injury induced by I/R as evidenced by the reduction of transaminases, structural changes, and apoptotic cell death. It decreased the level of inflammatory markers such as tumor necrosis factor-alpha (TNF-α), TNF-α/interleukin-10 (IL-10) ratio, and nuclear factor-κB gene expression. It also increased the anti-inflammatory cytokine, IL-10 levels in hepatic tissues. Furthermore, it reduced oxidative stress parameters except manganese superoxide dismutase activity.Conclusion:The results suggest that tramadol has hepatoprotective effects against hepatic I/R injury via anti-inflammatory, antiapoptotic, and antioxidant effects.KEY WORDS: Angioedema, anti-histamines, chronic urticaria, histaglobulin, urticaria activity score |
| |
| Keywords: | |
|
|
