慢性自发性荨麻疹患者血清IL-17、IL-23水平的检测及意义

目的:探讨白细胞介素-17(Interlenkin-17,IL-17)、白细胞介素-23(Interleukin-23,IL-23)在慢性自发性荨麻疹患者中的表达及意义。方法:选取慢性自发性荨麻疹患者和健康献血者各30例,用酶联免疫吸附法检测血清中IL-17、IL-23水平,并分析它们与病情、病程之间的关系。结果:慢性自发性荨麻疹患者的血清IL-17水平(19.3±8.1)pg/mL]、IL-23水平(28.9±11.1)pg/mL]均高于对照组(8.6±5.7)pg/mL,(10.9±6.2)pg/mL],组间比较差异有统计学意义(t值分别为5.92、7.72,P值均<0.01)。慢性自发性荨麻疹患者IL-17、IL-23与症状评分呈正相关关系(r=0.89、r=0.75,P值均<0.01),与病程无明显相关性(r=0.23、r=0.24,P值均>0.05),IL-17与IL-23呈正相关关系(r=0.81,P<0.01)。结论:IL-17、IL-23在慢性自发性荨麻疹发病机理中可能起着重要作用。

Serum Levels of IL-17,IL-23 in Patients with Chronic Spontaneous Urticaria

Objective:To study the serum levels of IL-17 and IL-23 in the patients with chronic spontaneous urticaria.Methods:30 patients with chronic spontaneous urticaria as a CSU group and 30 healthy people as the control group were assigned.The serum levels of IL-17 and IL-23 were determined by ELISA.Results: Serum levels of IL-17 and IL-23 in CSU group(19.3±8.1 pg/mL,28.9±11.1 pg/mL) were significantly higher than those in control group(8.6±5.7 pg/mL,10.9±6.2 pg/mL(t=5.92,7.72,respectively,P<0.01).Serum levels of IL-17 and IL-23 were positively correlated to the score of the patients with CSU(r=0.89、r=0.75 respectively,P<0.01),but not correlated to the course of disease(r=0.23、r=0.24 respectively,P>0.05).Serum level of IL-17 was positively correlated to that of IL-23 significantly(r=0.81,P<0.01).Conclusion:IL-17 and IL-23 may participate in the pathogenesis of chronic spontaneous urticaria.