Epstein-Barr virus load in cerebrospinal fluid of patients with chronic active Epstein-Barr virus infection |
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| Authors: | Ohga Shouichi Sanefuji Masafumi Ishimura Masataka Nomura Akihiko Torisu Hiroyuki Kira Ryutaro Takada Hidetoshi Mizuno Yumi Kazuyama Yukumasa Hara Toshiro |
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| Affiliation: | Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. ohgas@pediatr.med.kyushu-u.ac.jp |
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| Abstract: | Chronic active Epstein-Barr virus (EBV) infection is a rare chronic mononucleosis syndrome involving clonally proliferating EBV-infected T-/NK-cells. EBV DNA was quantified in nonpleocytotic cerebrospinal fluid (CSF) of 9 patients. Three patients with neurologic and/or neuroimaging abnormalities showed high CSF copy numbers. In 1 patient, CSF copy number exceeded the peripheral blood value. CSF EBV-load may predict the central nervous system involvement of EBVT-/NK-cells. |
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