肺积1号方防治肺癌紫杉醇化疗相关心脏不良反应的临床观察 |
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引用本文: | 庄静,刘瑞娟,孙长岗.肺积1号方防治肺癌紫杉醇化疗相关心脏不良反应的临床观察[J].中国循证心血管医学杂志,2012,4(6):529-530,535. |
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作者姓名: | 庄静 刘瑞娟 孙长岗 |
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作者单位: | 庄静 (潍坊市中医院,潍坊,370700); 刘瑞娟 (潍坊市中医院,潍坊,370700); 孙长岗 (潍坊市中医院,潍坊,370700); |
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基金项目: | 国家自然科学基金(81273987) |
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摘 要: | 目的观察肺积1号方对肺癌紫杉醇化疗引起的心脏不良反应和心功能的干预效果。方法 64例接受紫杉醇化疗的肺癌患者随机分为对照组(n=32)和实验组(n=32)。对照组仅接受化疗,实验组在化疗同时口服肺积1号方煎剂,早晚各1次,200mL,日一剂。治疗前后分别记录心电图和超声心动图中的左心室舒张末期内径(LVDd)、左心室收缩末期内径(LVSd)、舒张早期与晚期充盈速度比值(E/A)、射血分数(LVEF)和短轴缩短率(FS)等各项指标,以及发生心脏不良反应的患者比例。结果实验组心电图异常发生率明显低于对照组(12.5%vs.31.3%,P〈0.05),实验组化疗后LVDd、LVDs、E/A、LVEF和FS均与化疗前无统计学差异,对照组LVDd和LVDs较化疗前明显增加(P〈0.05);实验组心脏不良反应的发生率明显低于对照组(13.6%vs.37.5%,P〈0.05)。结论肺积1号方对肺癌紫杉醇化疗所导致的心脏不良反应有一定的防治作用,并可在一定程度上减轻心脏功能下降。
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关 键 词: | 号方 肺癌 紫杉醇 心脏 |
Preventive effect of Feiji-1 Fang on cardiac adverse reactions related to paclitaxel in lung cancer |
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Authors: | ZHUANG Jing LIU Rui-juan SUN Chang-gang |
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Institution: | . Weifang Chinese Medicine Hospital, Weifang 370700, China. |
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Abstract: | Objective To observe the influence of Feiji-1 Fang on cardiac adverse reactions induced by paclitaxel chemotherapy in lung cancer. Methods The patients ( n =64 ) with lung cancer treated with paclitaxel chemotherapy were randomized into control group and experimental group ( each n =32 ) . Control group was only treated with chemotherapy and experimental group was given Feiji-1 Fang ( 200 mL,bid ) besides of chemotherapy. The indexes of left ventricular end-diastolic inner diameter ( LVDd ) , left ventricular end systolic diameter ( LVSd ) , E/A ratio, left ventricular ejection fraction ( LVEF ) and fractional shortening ( FS ) of electrocardiogram ( ECG ) and echocardiogram, and proportion of patients with cardiac adverse reactions were recorded. Results The incidence of abnormal ECG was significantly lower in experimental group than that in control group ( 12.5% vs. 31.3%, P 0.05). After chemotherapy the indexes of LVDd, LVSd, E/A ratio, LVEF and FS had not changed in experimental group, while LVDd and LVSd increased significantly in control group ( P 0.05 ) . The incidence rate of cardiac adverse reactions was lower in experimental group than that in control group (13.6% vs . 37.5%, P 0.05). Conclusion Feiji-1 Fang has preventive effect on cardiac adverse reactions induced by paclitaxel chemotherapy, and can alleviate the dysfunction of heart. |
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Keywords: | Feiji-I Fang Lung cancer Paclitaxel Heart |
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