血管紧张素转换酶基因插燃失多态性与中国汉族人群心肌梗死相关洼的Meta分析

目的采用Meta分析的方法探讨血管紧张素转换酶基因插入/缺失（ACEI/D）多态性与中国汉族人群心肌梗死（MI）的相关性。方法系统检索中国生物医学文献数据、中国期刊全文数据库、中文科技期刊全文数据库和万方数据库中1995年至2012年6月间公开发表的病例-对照研究,对符合纳入标准的研究进行数据提取后采用Meta-Analyst3软件进行Meta分析,采用漏斗图检验发表偏倚。结果共纳入24项病例-对照研究,1821例MI患者和1951例对照。总体人群和亚组Meta分析结果均表明ACEI/D多态性与中国汉族人群MI相关性密切相关,携带D等位基因能够显著增加MI的易感性Ivs.D：OR=0.56,95%CI：0.49～0.64;IIvs.DD：OR=0.37,95%CI：0.29～0.46;IDvs.DD：OR=0.48,95%CI：0.39～0.59;（ID＋II）vs.DD：OR=0.43,95%CI：0.34～0.53;IIvs.（DD＋ID）：OR=0.57,95%CI：0.50～0.66]。有轻微的发表偏倚存在。结论本研究结果支持ACEI/D多态性与中国汉族人群MI发病风险相关,但并不能证明I/D多态性是MI的独立危险因素,亦不能证明D等位基因为致病基因、I等位基因为保护基因。

A Meta-analysis on correlation between angiotensin converting enzyme gene insertion/deletion polymorphism and myocardial infarction in Chinese Han population

Objective To investigate the correlation between angiotensin converting enzyme gene insertion/deletion （ ACE I/D ） polymorphism and myocardial infarction （ MI ） in Chinese Han population by applying Meta-analysis. Methods The databases of Chinese BioMedical Literature Database （ CBM ） , China Journal Full-Text Database （ CJFD ） , China Scientific Journal Database （ CSJD ） and WanFang Database were retrieved for collecting published case-control studies from 1995 to June, 2012. The data was extracted from eligible studies and then given Meta-analysis by using Meta-Analyst 3 software. Publication bias was detected by using funnel plot. Results There were totally 24 case-control studies included involving 1821 patients with MI and 1951 control cases. The results of Meta-analysis on the whole population and sub-group showed that there was a close correlation between ACE I/D polymorphism and MI in Chinese Han population. Carried allele D promoted significantly the susceptibility of MI I vs . D： OR =0.56, 95% CI ： 0.49-0.64; II vs . DD： OR =0.37, 95% CI ： 0.29-0.46; ID vs . DD： OR =0.48, 95% CI ： 0.39-0.59; （ ID＋II ） vs . DD： OR =0.43, 95% CI ： 0.34-0.53; II vs . （ DD＋ID ） ： OR =0.57, 95% CI ： 0.50-0.66]. There was slight publication bias existed. Conclusion This study supports that ACE I/D is related to MI risk in Chinese Han population, but can not prove that I/D polymorphism is a independent risk factor of MI, allele D is a pathogenic gene and allele I is a protective gene.