阿利吉仑对氨氯地平相关外周水肿干预的Meta分析

目的系统评价阿利吉仑对氨氯地平相关外周水肿干预效果。方法通过计算机检索及手工检索，全面收集阿利吉仑联合氨氯地平治疗高血压的随机对照试验（RCTs），按Cochrane协作网系统评价的方法进行评价。结果共纳入4项研究，2584例患者。Meta分析示：与单用氨氯地平组相比，阿利吉仑联合氨氯地平组外周水肿发生率有下降趋势（RR=0．84，95％CI：0．69～1．02，P=0．08）；因发生外周水肿而退m研究的比例下降（RR：0．63，95％CI：0．41～0．95，P=0．03）；因干预相关副作用而退出研究的发生率下降（RR=0．72，95％C1：0．54～0．94，P=O．02）。结论阿利吉仑有降低氨氯地平相关外周水肿的趋势，可提高患者依从性，但需更多的高质量临床试验获得严谨客观的证据。

A Meta-analysis on intervention effect on aliskiren to amlodipine-associated peripheral edema

Objective To review systematically the intervention effect of aliskiren on amlodipine- associated peripheral edema. Methods Through computer retrieving and manual retrieving, all the randomized controlled trials （ RCTs ） about the treatment of hypertension with aliskiren combining amlodipine were collected and the data from these studies was reviewed according to Cochrane Review Methodology. Results There were totally 4 RCTs included involving 2584 patients in our analysis. The results of Meta-analysis showed that the incidence of peripheral edema trended to decrease in aliskiren combining amlodipine group compared with amlodipine group （ RR=0.84, 95%CI： 0.69-1.02, P=0.08 ） . The withdrawal proportion due to peripheral edema decreased （ RR=0.63, 95%CI： 0.41-0.95, P=0.03 ） , and withdrawal rate due to treatment related side effects decreased （ RR=0.72, 95%CI： 0.54-0.94, P=0.02 ） . Conclusion Aliskiren has a tendency of reducing amlodipine-associated peripheral edema and can improve patients＂ compliance, while more high-quality clinical trials are needed to obtain rigorous and objective evidences.