垂体性和下丘脑性侏儒症鞍区MRI表现及相关激素缺乏的研究

运用统计学方法处理65例生长激素缺乏患者的鞍区MRI改变的结果，得到垂体性和下丘脑性生长激素缺乏的相关统计函数式，提出诊断数据化处理的意义和可能性。材料和方法：65例原发生长激素缺乏患者，其中下丘脑性生长激素缺乏（HGHD）15例，垂体性生长激素缺乏（PGHD）50例。使用TOSHIBA公司的0．35T超导MRI成像系统对患者进行3mm层厚的鞍区检查。得到每个病人MRI征象六个方面参数65组数据。分为统计组和检验组。用统计组的数据运用判别分析原理（多个数据的两类判别）求导它们的相关函数式，运用t检验或X检验，判别参数与诊断相关意义。用检验组验证方程式的诊断符合率。结果：得到两型侏儒的判别函数式。垂体高径（X1）、垂体后叶（X2）、垂体柄（X3）、鞍窝形态（X4）有高度统计学意义。判别函数式的诊断符合率为88．9％。结论：1．两型侏儒具有明显的鞍区表现的差异，MRI检查是有效的诊断方法。2．统计学结果具有明显的临床实用意义。统计方程式诊断原发生激素缺乏的正确率较高。

Interrelation Statistic Study between MRI Signals of Sellar with RGHD and PGHD

To make up and evaluate the statistic interrelation discriminants of pitutary growth hormonedeficiency(PGHD) and hypothalamic growth hormoen deficiency(HGHD) after analysing the sellar MRIsignals of them. Materials and Methods: Results of 65 patents MRI signals of sellar, including 50 patients with PGHD, 15 Patients with HGHD and stalistical methods including diseriminated analysis, test,X2 test had been evaluated in the study.All patients were divided into two groups, the statistical(47 cases)and the test groups (18 cases). Results: The height of pitutary(X1), the peterior lobe of pitutary(X2) .the pitutary stalk(X3) and sellar cavity(X4) are the important indexes to diagnose PHGD andHGHD. The rate of correct diagnosis according to the discriminants is about 88.9% .Conelusion: Thediscrminants are of important value for diagnosis of PGHD and HGHD.