| 窄谱中波紫外线对寻常性银屑病患者外周血T细胞CCR6表达的影响 |
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| 引用本文： | 刘海琴.窄谱中波紫外线对寻常性银屑病患者外周血T细胞CCR6表达的影响[J].中国皮肤性病学杂志,2011,25(11). |
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| 作者姓名： | 刘海琴 |
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| 作者单位： | 江苏省南通市疾病预防控制中心皮防所,江苏南通,226006 |
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| 摘 要： | 目的评价窄谱中波紫外线(NB-UVB)对寻常性银屑病患者外周血T细胞趋化因子受体-6(CCR6)表达水平的影响。方法采用流式细胞仪检测24例寻常性银屑病患者在NB-UVB治疗前、后外周血T细胞CCR6的表达水平,并与24名健康人正常对照组进行比较。结果治疗前寻常性银屑病患者和正常对照组外周血T细胞CCR6表达率为(42.10±11.08)%和(11.03±1.01)%,差异有统计学意义(P<0.05)。治疗12周后,银屑病患者外周血T细胞CCR6表达为(40.05±4.52)%,与治疗前比较,差异无统计学意义(P>0.05)。结论寻常性银屑病患者外周血PBMC中T细胞CCR6的表达率明显高于正常人群,这可能与银屑病的发病机制密切相关。但其不随病情而变化,故不作为银屑病病情变化的参考指标。
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| 关 键 词： | 紫外线 银屑病 趋化因子受体-6 |
Effect of Narrowband Ultraviolet B Phototherapy on Chemokine Receptor 6 in Peripheral blood of Psoriasis |
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| LIU Hai-qin.Effect of Narrowband Ultraviolet B Phototherapy on Chemokine Receptor 6 in Peripheral blood of Psoriasis[J].The Chinese Journal of Dermatovenereology,2011,25(11). |
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| Authors: | LIU Hai-qin |
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| Institution: | LIU Hai-qin(Department of Dermatology,Nantong Center for Disease Control and Prevention of Jiangsu Province,Nantong 226006,China) |
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| Abstract: | Objective To evaluate the impact of the narrow-band ultraviolet B (NB-UVB) on CCR6 expression of T lymphocytes in peripheral blood of psoriasis vulgaris. Methods Use the flow cytometric analysis to detect the expression rate of peripheral blood Peripheral T lymphocytes on CCR6 of 24 cases of psoriasis vulgaris before and after treatment in patients with NB-UVB and 24 healthy people. Results The expression rate of peripheral blood Peripheral T lymphocytes on CCR6 of 24 cases of psoriasis vulgaris in patients... |
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| Keywords: | Ultraviolet Psoriasis Chemokine receptor 6 |
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