阿维A治疗68例儿童重症银屑病的疗效及安全性分析

目的观察阿维A治疗儿童重症银屑病的临床疗效和安全性。方法选择临床上诊断明确的重症儿童银屑病68例,其中寻常性55例(PASI评分≥10),脓疱型9例,关节病型3例,红皮病型1例。按0.5～1.0mg/(kg·d)顿服阿维A,治疗后观察临床疗效和不良反应,包括治疗前后检测肝肾功能、血脂及对儿童生长发育的影响等。结果治疗12周后痊愈41例,显效16例,有效率83.82%。临床最常见不良反应是干燥型唇炎,占100%(68例),其次为皮肤瘙痒30.00%(21例),皮肤脆性增加占26.00%(18例)。治疗前后查肝功能、肾功能和血脂均未见异常,患儿的身高和体重也无明显变化。结论阿维A治疗儿童重症银屑病疗效肯定,耐受性好,但要严格控制其适应症。

Analysis of the Efficacy and Safety of Acitretin for 68 Sever Psoriasis Children

Objective To ivestigate the efficacy and safety of acitretin in treatment of children with sever psoriasis. Methods Sixty-eight psoriasis children were treated with acitetin 0.5~1.0mg/(kg.d) orally once a day. Among the patients,55 children suffered from psoriasis vulgaris ( PASI≥10), 9 children suffered from psoriasis pustulosa, 3 chidren suffered from psoriasis arthopathica and 1 child suffered from erythrodermic psoriasis. The clinical efficacy and adverse reaction were observaved after treatment, including hepatic/renal function and blood lipid , the impact on children′s growth changes after treatment. Results After 12 weeks treatment,57 patients achieved obvious curative effect,with a total effective rate of 83.82%.The most common side effect of the drug was dry cheilitis,which occurred in 100% of the patients(68). The less common adverse drug reaction were skin prutitis(30.00%,21)and increased skin fragility(26.00%,18).The hepatic/renal function and blood lipid of the children before and after treatment were all normal. And the children′s height and weight had also no change. Conclusion Acitretin is effective in treatment of children with sever psoriasis,and with tolerable adverse effect but it should be applied with strict indication.