Subcellular distribution of mercury in the rat kidney cortex after exposure to mercuric chloride

The pharmacologic effects and plasma concentrations produced by the ip administration of high doses of thymidine were determined in CDF₁ mice. Within 15 min after the injection of thymidine at a dose of 4.075 g/kg (between LD0 and LD50), mean arterial blood pressure and heart rate fell precipitously and remained depressed for over 6 hr. During the experimental period, sedation and anuresis were also consistently observed in thymidine-treated mice. After a dose of 4.7 g/kg, millimolar plasma thymidine concentrations were maintained for 16 to 20 hr; by contrast, at a lower but nonlethal dose (3.8 g/kg), millimolar plasma thymidine concentrations were maintained for only 9 hr. It is suggested that sustained elevation of circulating thymidine in the range 1–10 mm for periods greater than $\text{1}\text{2}$ day may be associated with toxicity in mice.