| 转换酶抑制剂和长效钙拮抗剂对动脉硬化相关因子NO、ET影响的对比研究 |
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| 引用本文： | 贺晓楠,陈宇,张桂华. 转换酶抑制剂和长效钙拮抗剂对动脉硬化相关因子NO、ET影响的对比研究[J]. 吉林医学, 2003, 24(6): 503-504 |
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| 作者姓名： | 贺晓楠 陈宇 张桂华 |
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| 作者单位： | [1]延边大学医学院附属医院附属医院循环内科，吉林延吉133000 [2]吉林大学第三临床学院循环内科，吉林长春130021 |
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| 摘 要： | 目的:探讨卡托普利和氨氯地平对动脉硬化家兔模型的预防治疗作用。方法:动态观察各模型组血浆中NO、ET水平。结果:卡托普利和硒+VitE、氨氯地平皆可抑制血中NO、ET因子水平,但在NO、ET方面氨氯地平较强。结论:两种药物可抑制AS的发生发展,但在动脉斑块的稳定方面氨氯地平作用较强。
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| 关 键 词： | 动脉粥样硬化 卡托普利 氨氯地平 一氧化氮 内皮素 |
| 文章编号： | 1004-0412(2003)06-0503-02 |
| 修稿时间： | 2003-04-09 |
The contrast experiment of effects of captopril and amlodipine on related factors of atherosclerosis NO and ET |
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| HE Xiao-nan ,CHEN Yu ,ZHANG Gui-hua. The contrast experiment of effects of captopril and amlodipine on related factors of atherosclerosis NO and ET[J]. Jilin Medical Journal, 2003, 24(6): 503-504 |
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| Authors: | HE Xiao-nan CHEN Yu ZHANG Gui-hua |
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| Affiliation: | HE Xiao-nan 1,CHEN Yu 2,ZHANG Gui-hua 2 |
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| Abstract: | Objective To discuss the effects of captopril and amlodipine on related factors of atherosclerosis NO and ET.Method Serial measurements of blood levels of NO and ET of the rabbits were performed through out this experiment.Results The level of ET was inhibited,level of NO was increased both in captopril prevention group and selemium+Vitamin E treatment group and am-lodipine group.Conclusion Amlodipine can inhibit the emergence and development of AS,but as for the stability of AS,the effect of Amlodipine was stronger. |
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| Keywords: | Atherosclerosis Endothelin Nitric Oxide Amlodipine Captopril |
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