应用首次通过法肺灌注显像对急性肺栓塞合并肺动脉高压的评价

目的：应用首次通过法肺灌注显像（First-pass radionuclide pulmonary perfusion imaging,FPPPI）对急性肺栓塞（Acute pulmonary embolism APE）合并肺动脉高压（Pulmonary hypertension,PH）的评价。方法：20例健康自愿者,男12例,女8例,平均年龄为48.47±13.47岁（21-71岁）,20例（2007-10-2009-02）临床诊断为急性肺栓塞病人,男11例,9例,平均年龄为49.95±16.13岁（23-82岁）,所有受试者均行FPPPI检查,按FPPPI计算肺平衡时间（Lung equilibrium time LET）。结果：FPPPI法测定的肺平衡时间（LET）,正常组LET 12.18±3.28 sec,APE组LET 32.90±14.29 sec两组进行t检验,t=6.32,P〈0.01,有统计学差别。结论：FPPPI是评价急性肺栓塞合并肺动脉高压的可靠、简便、无创性的方法。

EVALUATION OF PULMONARY HYPERTENSION AND STRATIFICATION OF RISK BY FIRST-PASS RADIONUCLIDE PULMONARY PERFUSION IMAGING IN PATIENTS WITH PULMONARY HYPERTENSION OF ACUTE PULMONARY EMBOLISM

Objective：The purpose of this study was to evaluate pulmonary hypertension（ PH） and stratification of risk by first-pass radionuclide pulmonary perfusion imaging（ FPPPI） in patients with PH of acute pulmonary embolism（ APE） . Methods：twenty healthy volunteers（12 males,8 females,average age of 48. 47±13. 47）Twenty patients（11 males,9 females,average age of 49. 95±16. 13,accumulated from 2007-10-2009-02 ） with acute pulmonary embolism were included in our study. FPPPI were performed in all Subjects. Calculated by FPPPI lung equilibration time（ LET） . Results：LET by FPPPI in healthy volunteers and APE patients were 12. 18±3. 28 sec and 32. 90±14. 29 sec,respectively. It is the significance between healthy volunteers and APE patients （ P〈0 . 01 ） . Conclusion：FPPPI was a reliable,convenient andnon-invasivemethod in evaluating pulmonary hypertension in acute pulmonary embolism.