Evidence for an epileptogenic action of 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine

Based on behavioral observation alone, poorly characterized paroxysmal motor abnormalities have been reported in mice after acute MPTP administration. This study investigated electroencephalographic (EEG) and behavioral effects of acute MPTP in young and older mice. Single MPTP injections (30 mg/kg i.p.) produced limbic and/or generalized seizures in older (6 mo) and frank epileptiforrn interictal hippocampal spikes in younger (6–8 wks) mice. These latter showed behavioral seizures only after the 3rd drug administration. Studies of the acute effects of MPTP must take in consideration that seizures “per se” modify brain biochemical and metabolic activity and alter the permeability of the blood brain barrier, adding several confounding variables.