Stress hormones,sleep deprivation and cognition in older adults |
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Authors: | Marcello Maggio,Elena Colizzi,Alberto Fisichella,Giorgio Valenti,Graziano Ceresini,Elisabetta Dall&rsquo Aglio,Livia Ruffini,Fulvio Lauretani,Liborio Parrino,Gian Paolo Ceda |
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Affiliation: | 1. Department of Clinical and Experimental Medicine, Section of Geriatrics, Endocrinology of Aging Unit, University of Parma, Italy;2. Geriatric Rehabilitation Department, University Hospital of Parma, Parma, Italy;3. Nuclear Medicine Unit, University Hospital of Parma, Parma, Italy;4. Department of Neurosciences, University of Parma, Italy |
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Abstract: | Cognition can be deteriorated in older persons because of several potential mechanisms including the hormonal changes occurring with age. Stress events cause modification in hormonal balance with acute and chronic changes such as increase in cortisol and thyroid hormones, and simultaneous alterations in dehydroepiandrosterone sulphate, testosterone and insulin like growth factor-1 levels. The ability to cope with stress and regain previous healthy status, also called resiliency, is particularly impaired in older persons Thus, stressful conditions and hormonal dysregulation might concur to the onset of cognitive impairment in this population. |
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Keywords: | Stress hormones Sleep deprivation Cognitive function Older adults |
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