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Gentamicin and leucine inhalable powder: What about antipseudomonal activity and permeation through cystic fibrosis mucus? |
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| Authors: | Paola Russo Mariateresa StiglianiLucia Prota Giulia AuriemmaCarlo Crescenzi Amalia PortaRita P Aquino |
| Institution: | Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte don Melillo, Invariate 7, 84084 Fisciano (SA), Italy |
| Abstract: | The aim of this study was to evaluate the permeation properties of gentamicin (G) in a novel dry powder form for inhalation through an artificial mucus model. Moreover, since respiratory infections sustained by Pseudomonas are a major cause of sickness and death in CF patients, the susceptibility of P. aeruginosa to engineered G powders was investigated. |
| Keywords: | ACI Andersen cascade impactor AM- basic artificial mucus AM1 and AM1 5 artificial mucus with 1 or 1 5% of hydroxyethylcellulose respectively CF cystic fibrosis DPI dry powder inhaler ED emitted dose FPD fine particle dose FPF fine particle fraction G gentamicin sulfate HEC hydroxyethylcellulose ISO isopropyl alcohol Leul -leucine MMAD mass median aerodynamic diameter |
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