Metabolic transitions at menopause: In post-menopausal women the increase in serum uric acid correlates with abdominal adiposity as assessed by DXA |
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Authors: | Eleonora Cremonini Gloria Bonaccorsi Carlo M Bergamini Cristina Castaldini Stefania Ferrazzini Alessandra Capatti Leo Massari Arianna Romani Roberto Marci Enrica Fila Carlo Ferrari Carlo Cervellati |
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Institution: | 1. Department of Biochemistry and Molecular Biology, University of Ferrara, via Luigi Borsari 46, 44121 Ferrara, Italy;2. Gynecologic and Obstetrics Clinic, University of Ferrara, via Aldo Moro 8, 44124 Ferrara, Italy;3. Menopause and Osteoporosis Centre, University of Ferrara, via Boschetto 29-31, 44124 Ferrara, Italy;4. Department of Biomedical Sciences and Advanced Therapies, Section of Orthopaedic Clinic, Hospital “S. Anna”, University of Ferrara, via Aldo Moro 8, 44124 Ferrara, Italy;5. Department of Biochemistry, Biology and Genetics, Marche Polytechnic University, via Ranieri 65, 60131 Ancona, Italy |
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Abstract: | ObjectivesThe present study aimed to investigate any associations between parameters of body fat mass distribution and levels of serum uric acid (sUA), a well-documented cardiovascular risk factor, among non-obese women ranging from pre- to post-menopausal status.MethodsIn this cross-sectional population-based study we assessed body fat distribution by dual-energy-X-ray absorptiometry (DXA), and sUA levels in 101 pre- and 134 post-menopausal non-obese apparently healthy women.ResultsMultivariate stepwise regression analysis revealed that sUA was independently associated to the indicators of overall fatness, i.e. body mass index (β = 0.339, p < 0.001) and DXA-assessed total and percentage body fat (β = 0.366, p < 0.001 and β = 0.412, p < 0.001, respectively), only among post-menopausal women. Within this sample subset, trunk (i.e. central) fat mass emerged as a strong predictor of sUA (β = 0.408, p < 0.001), after taking the potential confounders (including body mass index) into account.ConclusionCentral fat accumulation was found to be independently associated with higher sUA levels among non-obese women in post- but not among those in pre-menopause. |
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Keywords: | CVD cardiovascular diseases sUA serum uric acid DXA dual-energy-X-ray absorptiometry FM fat mass E2 17-β estradiol BMI body mass index VF visceral fat |
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