小儿结核性脑膜炎的短程间歇疗法

对33例结核性脑膜炎患儿进行短程间歇化疗。以雷米封、利福定、吡嗪酰胺及链霉素在日用一个月后改为每周二次,链霉素续用1～2个月, 雷米封、利福定、吡嗪酰胺续用8个月。对照组16例结核性脑膜炎患儿上述四药日用坚持一年以上。研究表明,短程间歇化疗与全程日用对照组的疗效相似(P>0.05)。其后遗症发生率治疗组与对照组间亦无显著差异(P>0.05),且与入院时脑脊液白细胞数、蛋白质、糖和氯化物水平无紧密关联(P>0.05),可是,有昏迷抽风者,后遗症的发生率明显增加(P<0.05)。

An Intermittent Short-course Chemotherapy Regimen for Tuberculous Meningitis in Children

An intermittent short-course chemotherapy regimen was carried outin 33 children suffering from TB meningitis, consisting of INH, RFD, PZA and streptomycin (SM) daily for one month, followed by SM twice-weekly for another one to two months, INH, RFD and PZA twice-weekly for another eight months. The control group. 16 children suffering from tuberculous meningitis, was given INH, RFD, PZA and SM daily for one year or more. Follow-up study revealed that the difference between the fatality rates of these two groups was statistically insignifant (P>0.05).As to the incidenees of sequela, the difference between the two groups was also statistically insignificant (P>0.05) ; it was not closely related to the levels of WBC, protein, glucose and chloride in CSF before medication, yet, those of the intermittent short-course regime group increased significantly (P<0.05) if coma and spasm had beenpresent.