托特罗定治疗前列腺术后留置导尿致膀胱痉挛临床疗效分析

目的 :评价托特罗定 (tolterodine)治疗前列腺术后留置导尿致膀胱痉挛的疗效。　方法 :对 82例前列腺术后留置导尿出现膀胱痉挛的患者给于托特罗定治疗 ,2mg/次 ,2次 /d ,至拔除导尿管前 2 4h。评价指标包括痉挛是否发生、发生频率、持续时间等。　结果 :用药 2 4h后 ,膀胱痉挛完全缓解 2 1例 (2 5 .6 % ) ;部分缓解 4 5例 (5 4 .9% ) ;未缓解 16例 (19.5 % )。 72h后 ,膀胱痉挛完全缓解 4 5例 (5 4 .9% ) ;部分缓解 30例 (36 .6 % ) ;未缓解 7例 (8.5 % )。治疗过程中无严重不良反应发生。　结论 :托特罗定为治疗前列腺术后留置导尿致膀胱痉挛快速、有效、持久、安全的药物。

Tolterodine for Bladder Spasm Caused by the Indwelling Catheter after Prostate Operation

Objective: To evaluate the efficacy of tolterodine on bladder spasm caused by the indwelling catheter after prostate operation. Methods: Eighty-two patients with bladder spasm caused by the indwelling catheter after prostate operation received tolerodine (2 mg twice daily), until 24 hours before the removal of the catheter. Results: After 24 hours of treatment, bladder spasm was alleviated totally in 21 patients ( 25.6%), partially in 45 ( 54.9%), and unrelieved in 16 ( 19.5%). After 72 hours of treatment, bladder spasm was alleviated totally in 45 patients ( 54.9%), partially in 30 ( 36.6%), and unrelieved in 7 ( 8.5%). No severe adverse events occurred during the treatment. Conclusion: The tolterodine therapy for patients with bladder spasm caused by the indwelling catheter after prostate operations is rapid, effective, persistent and safe.