中药酸枣仁、龙齿、石菖蒲对小鼠脑组织单胺类神经递质及其代谢物的影响

应用高效液相色谱－电化学检测器观察中药酸枣仁、龙齿、石菖蒲对小鼠脑组织中单胺类神经递质及其代谢物含量的影响。结果显示：酸枣仁可降低多巴胺和３，４－二羟基苯乙酸的含量，龙齿降低多巴胺和高香草酸水平。开窍中药石菖蒲能降低５－羟吲哚乙酸及上述三种神经递质。乙醇组则明显升高３，４－二羟基苯乙酸和５－羟吲哚乙酸的水平。从上述结果说明安神、开窍单味中药可能是通过降低单胺类神经递质起到使中枢神经镇静的作用。

Effects of TCM Drugs Semen Ziziphi Spinosae,Dens Draconis and Rhizoma Acori Graminei on the Content of Monoamine Neurotransmitters and Their Metabolites in Mouse Brain Tissue

The effects of TCM drugs Semen Ziziphi Spinosae,Dens Dracpmos and Rhizoma Acori Graminei on the content of monoaminee neurotransmitters and their metabolites in mouse brain tissue were studied with HPLC-electrochemical detector.The results showed that Semen Ziziphi Spinosae could decrease the content of 3.4-dihydroxyphenyl acetic acid,Dens Draconis could decrease the content of dopamine and homovanillic acid,and Rhizoma Aeon Graminei could decrease the content of 5-hydroxyinidole acetic acid as well as the content of the above-mentioned three substances.However,in the ethanol given group,the levels of 3,4-dihydroxyphenyl acetic acid,5-hydroxyindole acetic acid and homovanillic acid in mouse brain tissue were higher than those of in control group.The above results show that Chinese drugs for tranquilization and opening orifices regulate the central nervous system through decreasing the content of monoamine neurotransmitters.