| 糖基化终末产物与肝病 |
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| 引用本文： | 蔡晓波,范建高. 糖基化终末产物与肝病[J]. 国际消化病杂志, 2006, 26(1): 8-10 |
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| 作者姓名： | 蔡晓波 范建高 |
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| 作者单位： | 上海交通大学附属第一人民医院脂肪肝诊治中心,200080;上海交通大学附属第一人民医院脂肪肝诊治中心,200080 |
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| 摘 要： | 肝脏是糖基化终末产物的主要代谢部位,肝病时伴随的氧化应激、糖耐量损害以及肝肾功能降低导致糖基化终末产物增加,而糖基化终末产物可通过促进氧应激/脂质过氧化、炎症反应以及纤维化等途径,加重肝脏损伤。
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| 关 键 词： | 糖基化终末产物 肝病 氧应激 |
| 收稿时间： | 2005-01-12 |
| 修稿时间： | 2005-01-12 |
Advanced glycation end products and liver disease |
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| CAI Xiao-bo,FAN Jian-gao. Advanced glycation end products and liver disease[J]. International Journal of Digestive Disease, 2006, 26(1): 8-10 |
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| Authors: | CAI Xiao-bo FAN Jian-gao |
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| Abstract: | Liver is the main site for metabolism of circulating advanced glycation end products.Oxidative stress,impaired glucose torlance and impaired liver and renal function which occur accompanied with liver disease lead to increasing of advanced glycation end products.But increased advanced glycation end products may also promote oxidative stress/lipid peroxide,inflammatory reaction and fibrogenesis and aggravate liver injury. |
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| Keywords: | Advanced glycation end products Liver disease Oxidative stress |
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